Chronic Myeloid Leukemia: Pathophysiology, Biomarkers, Mutations, Early Molecular and Treatment Response

Embark on a journey through the intricate landscape of Chronic Myeloid Leukemia (CML) with this authoritative volume, offering a comprehensive exploration from pathophysiology to advanced treatment paradigms. Beginning with a detailed introduction, the book unfolds with a narrative literature review that spans the evolution of CML research, culminating in the concept of treatment-free remission. Readers are guided through the molecular underpinnings of CML, including chromosomal defects and the role of leukemia stem cells. The text explores current treatment options—from alpha interferon to tyrosine kinase inhibitors—and delves into early molecular responses and predictors of treatment-free remission. Key chapters dissect mutations in the BCR-ABL oncogene, mechanisms of drug resistance, and the rationale for hematopoietic stem cell transplantation in refractory cases. Innovations in treatment monitoring, including the use of electronic medical records, and emerging therapeutic approaches underscore the book's forward-thinking approach. This indispensable resource concludes with insights into prognostic assessments, novel biomarkers, and future directions in CML research. Perfect for clinicians, researchers, and students alike, this book offers a comprehensive overview of CML that bridges foundational knowledge with cutting-edge advancements in the field.