Genetic Aspects of Toxicology: Chromosome Structural Alterations, Mutations, Genetic Alteration of Germ Cells and Somatic Cells, Genetic Susceptibilities and Resistance to Toxicants

Genetic Aspects of Toxicology: Chromosome Structural Alterations, Mutations, Genetic Alteration of Germ Cells and Somatic Cells, Genetic Susceptibilities and Resistance to Toxicants explores the intricate relationship between genetics and toxicology, offering a comprehensive examination of genetic vulnerabilities and responses to toxic substances. Beginning with an insightful introduction into the field, the book navigates through topics ranging from nucleic acid alterations in germ and somatic cells to the profound implications of DNA damage. It delves into methodologies such as the Bruce Ames test and molecular diagnostics, highlighting their role in assessing carcinogenic risks and genetic toxicities. Emphasizing the integration of toxicogenomics and pharmacogenetics, the text underscores genetic predispositions to adverse effects and the systemic impacts on organs like the skin, cardiovascular system, and nervous system. Detailed discussions on heritable toxicity, developmental toxicology, and risk assessment for future generations provide a forward-thinking perspective on safeguarding human health. With a meticulous blend of scientific rigor and practical insights, this book serves as a pivotal resource for researchers, toxicologists, and healthcare professionals navigating the complex interplay between genetics and toxicology in the modern age of biomedical research and environmental health management.