Antimicrobial Chemotherapy: Mechanism of Antibiotic Resistance, Cancer Risk, Oncologic Treatment Efficacy and Sustainable Development

This volume presents an advanced and comprehensive study of antimicrobial chemotherapy, with particular emphasis on the molecular mechanisms of antibiotic action and resistance, their clinical implications, and intersections with cancer therapy and sustainable development. It begins by detailing the biochemical foundations of antimicrobial agents, their targets—including bacterial cell walls, membranes, nucleic acids, and ribosomal functions—and the pharmacodynamics of specific drug classes such as beta-lactams, macrolides, quinolones, tetracyclines, and aminoglycosides. In-depth analyses explore diverse resistance mechanisms, including enzymatic inactivation, receptor modification, metabolic pathway alteration, and reduced drug uptake. The text also investigates the growing concern of resistance in pathogens such as Mycobacterium tuberculosis, and highlights the dangers posed by β-lactamase enzymes and vancomycin resistance. Through a critical examination of combination therapies, drug toxicology, and strategies for resistance mitigation, the volume engages with real-world therapeutic challenges. A distinctive feature is its interdisciplinary approach, linking antimicrobial use to oncologic outcomes, cancer risk, microbiome disruption, and the efficacy of chemotherapy. The book also includes applied microbial biotechnology techniques for enzyme production and protein purification, essential for laboratory and clinical research. Designed for graduate students, researchers, and healthcare professionals, this resource synthesizes cutting-edge knowledge relevant to infectious disease control, oncology, and global health sustainability.