Bio-affinity Sensors: Electrochemical Analysis Based on Bio-affinity, Affinity‑Based Electrochemical Sensors for Biomolecular Detection and Recent Advances in Applied Electrochemistry

The rapid advancements in biosensor technologies and electrochemical systems have led to breakthroughs in molecular diagnostics, environmental monitoring, and energy solutions. This book provides a comprehensive exploration of BioFET (Biologically-sensitive Field-Effect Transistor) devices and cutting-edge electrochemical technologies, offering insights for researchers, engineers, and students. It introduces foundational concepts like FET operation, MOSFET charge dynamics, and charge sheet models, followed by discussions on capacitance, threshold voltage monitoring, and interactions between molecules and oxide surfaces. Special focus is placed on charged membranes, such as oligonucleotides, with comparative analyses to experimental data. Innovative approaches to biomolecular detection are explored, including electrochemical analysis based on bioaffinity and affinity-based sensors for complex mediums like whole blood. The book examines on-chip sample purification techniques, such as filtration, microfluidic, and electrokinetic plasma separation, while addressing signal enhancement via conductive nanomaterials, magnetic concentration, and aptamer probes. Additional topics include electrode surface modifications and nanoporous membranes for molecular separation. Broader applications in applied electrochemistry, spanning energy conversion, material characterization, and environmental remediation, are discussed alongside disease diagnostics, emphasizing label-free and label-based biomarker detection. With its focus on innovation and practical applications, this book bridges theoretical understanding and real-world implementation, making it an essential resource for biosensor and electrochemical research.