Stereotactic Body Radiation Therapy [SBRT]: Ablative Radiotherapy, Radio-response at High Dose, SBRT Dose Range and Role of Hypoxia in Radio-resistance in Cancer Therapy

This comprehensive resource is essential for oncologists, radiation therapists, and researchers aiming to optimize cancer treatment strategies. By bridging theoretical frameworks with practical applications, this book reshapes the landscape of radiation oncology standards Explore the forefront of Stereotactic Body Radiation Therapy (SBRT) through this authoritative volume. Starting with a thorough introduction, the book guides readers through advanced concepts of ultra-high dose radio-response and mammalian survival curves, establishing a solid theoretical groundwork to grasp SBRT's effectiveness. At the core of its exploration lies the Linear Quadratic Model, providing valuable insights into dose modeling and strategies to overcome biological challenges in SBRT. In-depth discussions on radioprotection and the pivotal role of tumor hypoxia shed light on potential risks and innovative tactics for improving treatment outcomes. From the use of oxygen-mimicking agents to combat hypoxic tumor environments, to unraveling mechanisms of radioresistance, each chapter seamlessly blends clinical insights with cutting-edge research. Case studies underscore SBRT's practical applications across diverse cancers, including adrenal metastases, skin, and kidney cancers.