Pediatric Hematological Malignancies: Clinical Manifestation, Advanced Therapies, Treatment Strategies and Systemic Effects of Radiation Therapy

This comprehensive volume delves into the multifaceted realm of pediatric hematological malignancies, offering a meticulous exploration of clinical manifestations, cutting-edge therapies, treatment strategies, and the systemic impacts of radiation therapy. Beginning with an insightful introduction to the field, the book navigates through various aspects of childhood cancers of the blood system, including non-Hodgkin lymphoma and leukemia. Readers are guided through detailed discussions on the causes and stages of childhood hematological cancers, elucidating warning signs, symptoms, and staging techniques crucial for effective diagnosis and management. The text meticulously examines modern treatment approaches, from immunotherapy advancements to the transformative effects of radiation on hematologic cancers, extending beyond cellular destruction to systemic immunomodulation. Key topics such as mucositis, hair thinning, and other treatment-related side effects are addressed alongside proactive measures to mitigate these challenges. Innovations like CAR-T cell therapy and personalized treatment strategies underscore the book's forward-thinking approach, supported by insights into radiation dosing, scheduling, and combined therapeutic modalities. This essential resource concludes with practical guidance on post-treatment care, urgent pediatric oncologic emergencies, and a thorough clinical and imaging review for pediatricians. Backed by a robust reference section, this book serves as a definitive guide for clinicians, researchers, and healthcare professionals navigating the complex landscape of pediatric hematological malignancies.